Antibody-drug conjugates and methods

Details Antibody-drug conjugates and methods Antibody-drug conjugates and methods

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 35/00 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2567520

The present invention relates to antibody-drug conjugate compounds of Formula I: Ab-(L-D)p where one or more maytansinoid drug moieties (D) are covalently linked by L to an antibody (Ab) which binds to an ErbB receptor, or which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be used in methods of diagnosis or treatment of cancer, and other diseases and disorders.

L'invention concerne les composés conjugués de médicaments anticorps représentés par la formule (I): Ab-(L-D)p. Dans cette formule, une ou plusieurs fractions de médicaments de maytansinoïde (D) sont liées de façon covalente par L à un anticorps (Ab) qui se lie à un récepteur ErbB, ou qui se lie à un ou plusieurs antigènes associés à la tumeur ou récepteurs de surface cellulaire. Ces composés peuvent être utilisés dans des procédés de diagnostic ou de traitement du cancer, et d'autres maladies.

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