Antibody-drug conjugates and methods of use

Details Antibody-drug conjugates and methods of use Antibody-drug conjugates and methods of use

C - Chemistry, Metallurgy

07

K

C07K 5/02 (2006.01) A61K 47/48 (2006.01) C07K 5/06 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2623652

The present disclosure provides antibody-drug conjugates that are potent cytotoxins, wherein the drug is linked to the antibody through a linker. The disclosure is also directed to compositions containing the antibody-drug conjugates, and to methods of treatment using them.

L'invention concerne des conjugués anticorps-médicament consistant en des cytotoxines puissantes, le médicament étant lié à l'anticorps par l'intermédiaire d'une séquence de liaison. Elle concerne également des compositions contenant ces conjugués et des méthodes de traitement les mettant en application.

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