Antibody for adcc and inducing cytokine production

Details Antibody for adcc and inducing cytokine production Antibody for adcc and inducing cytokine production

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/34 (2006.01)

Patent

CA 2498787

The invention concerns chimeric monoclonal antibodies, humanized or human produced in selected cell lines, said antibodies exhibiting high affinity for the CD16 receptor of effector cells of the immune system and hence capable of inducing high ADCC, but also the property of inducing cytokine and interleukin secretion, in particular IFN.gamma., which can enhance the ADCC activity of effector cells and hence be used for treating cancers and infections by pathogenic agents.

La présente invention concerne des anticorps monoclonaux chimériques, humanisés ou humains qui sont produits dans des lignées cellulaires sélectionnées, lesdits anticorps présentant une forte affinité pour le récepteur CD 16 des cellules effectrices du système immunitaire et ainsi capables d'induire une forte ADCC, mais également la propriété d'induire la sécrétion de cytokines et d'interleukines, en particulier l' IFN.gamma., qui peut renforcer l'activité ADCC des cellules effectrices et ainsi s'appliquer au traitement des cancers et des infections par des agents pathogènes.

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