Antibody fragments in therapy

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/24 (2006.01) A61K 39/395 (2006.01) C07K 16/06 (2006.01) C07K 16/44 (2006.01) C12N 9/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2163032

A method of neutralising TNF.alpha. in a patient benifiting from such neutralising, comprising administering to the patient IgG Fab fragment reactive towards TNF.alpha.. Suitably, the patient is suffering from septic shock or from the symptoms of septic shock. It is preferred if the Fab fragment is derived from polyclonal IgG.

L'invention concerne un procédé de neutralisation du facteur de nécrose tumorale alpha (TNFalpha) appliqué à un patient et consistant à administrer au patient un fragment d'IgG Fab réagissant au TNFalpha; en particulier, le patient souffre du choc septique ou présente des symptômes du choc septique. Il est préférable que le fragment de Fab soit dérivé de l'IgG polyclonale.

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