Antibody gene transfer and recombinant aav therefor

Details Antibody gene transfer and recombinant aav therefor Antibody gene transfer and recombinant aav therefor

C - Chemistry, Metallurgy

12

N

C12N 15/864 (2006.01) A61K 39/395 (2006.01) C07K 16/10 (2006.01) C12N 7/01 (2006.01) C12N 15/13 (2006.01) C12P 21/02 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2481813

The present invention relates generally to the use of recombinant adeno- associated viruses (rAAV) for gene delivery and more specifically to the use of rAAV to deliver antibody genes to target cells in mammals. Administration of rAAV encoding antibodies that neutralize the HIV-1 virus is exemplified.

L'invention concerne en général l'utilisation de virus recombinants adéno-associés (rAAV) destinés au transfert génique et plus particulièrement à l'utilisation de ces rAAV afin de transférer des gènes d'anticorps dans des cellules cibles chez des mammifères. L'invention concerne également l'administration de rAAV codant des anticorps qui neutralisent le virus HIV-1.

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