Antibody glycosylation variants having increased...

Details Antibody glycosylation variants having increased... Antibody glycosylation variants having increased...

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 5/12 (2006.01) C12N 5/16 (2006.01) C12N 5/20 (2006.01) C12N 5/24 (2006.01) C12N 9/10 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) C12N 15/54 (2006.01)

Patent

CA 2455365

The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to glycosylation engineering to generate proteins with improved therapeutic properties, including antibodies with increased antibody-dependent cellular cytotoxicity.

L'invention concerne le domaine de la modification par glycosylation des protéines. D'une manière plus spécifique, l'invention concerne une modification par glycosylation qui permet d'obtenir des protéines présentant des propriétés thérapeutiques améliorées, notamment des anticorps présentant une cytotoxicité cellulaire accrue dépendante des anticorps.

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