Antibody having a t-cell receptor-like specificity, yet...

Details Antibody having a t-cell receptor-like specificity, yet... Antibody having a t-cell receptor-like specificity, yet...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2474782

An isolated molecule which comprises an antibody specifically bindable with a binding affinity below 20 nanomolar, preferably below 10 nanomolar, to a human major histocompatibility complex (MHC) class I being complexed with a HLA- restricted antigen and optionally further comprises an identifiable or therapeutic moiety conjugated to the antibody.

L'invention concerne une molécule isolée comprenant un anticorps pouvant se lier spécifiquement avec une affinité de liaison nanomolaire inférieure à 20, de préférence nano-molaire inférieure à 10, à un complexe majeur d'histocompatibilité (CMH) humain de classe I transformé en complexe avec un antigène à restriction HLA et comprenant également facultativement une fraction identifiable ou thérapeutique conjuguée à l'anticorps.

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