Antibody heteroconjugates for the killing of hiv-infected cells

Details Antibody heteroconjugates for the killing of hiv-infected cells Antibody heteroconjugates for the killing of hiv-infected cells

A - Human Necessities

61

K

167/139, 167/103

A61K 39/395 (2006.01) A61K 39/42 (2006.01) C07K 16/10 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1338518

The present invention relates to novel antibody heteroconjugates and their use in methods for killing HIV-infected cells. The heteroconjugates are comprised of an antibody specific for an HIV antigen that is expressed on HIV-infected cells cross-linked to an antibody specific for an effector cell of the peripheral blood capable of killing an HIV-infected target cell. The antibody heteroconjugates or the invention physically bridge the effector cell to the target cell and may activate the lytic mechanism of the effector cell in the killing of the HIV-infected target cell. The methods, heteroconjugates, pharmaceutical compositions and combinations described herein provide a novel approach to the treatment of HIV-infected individuals by amplifying endogenous HIV-specific effector mechanisms and may also be of prophylactic value in individuals newly infected or accidentally exposed to the HIV virus.

578194

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