Antibody hybrid molecules and process for their preparation

Details Antibody hybrid molecules and process for their preparation Antibody hybrid molecules and process for their preparation

A - Human Necessities

61

K

167/139, 195/1.1

A61K 39/44 (2006.01) A61K 47/48 (2006.01)

Patent

CA 1239355

14 ANTIBODY HYBRID MOLECULES AND PROCESS FOR THEIR PREPARATION ABSTRACT OF THE DISCLOSURE Antibodies which contain reduced sulfhydryl groups in proximity to the carboxyl terminal end of their heavy chain are coupled to another moiety which has an available sulfhydryl for forming a disulfide bond with the antibodies. IgM is a typical antibody which contains a suitable structure by virtue of its cysteine residue in proximity to the carboxyl terminal end of its heavy chain. A typical hybrid is formed with IgM and the A chain of a toxin such as ricin by the formation of a covalent disulfide bond therebetween. Use of antibodies having structures such as IgM result in hybrid formation in which the moiety joined to the antibody is site directed with respect to its bonding location on the antibody. Such hybrids have utility including in vivo therapeutic applications in which the functionality of the antibody is not deleteriously im- paired by the moiety bonded thereto.

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