A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/00 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) G01N 33/53 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2586285
Compositions and methods for inducing cell membrane wounding, cell permeabilization and cell killing are provided. The composition comprises a polyvalent agent that binds to a highly expressed cell surface antigen present on the surface of a cell. Preferably, the cell surface antigen is associated with the cytoskeleton of the cell. A preferred polyvalent agent is an IgM, and enhanced cell wounding and killing can be provided by the addition of a crosslinking agent. At sublethal concentrations in vivo, the cell wounding antibodies permeabilize cells and dramatically enhance response to chemotherapeutic agents, even in patients~ refractory to the chemotherapeutic agents.
L'invention concerne des compositions et des méthodes permettant d'induire la fragilisation de la membrane cellulaire, la perméabilisation cellulaire et la mort cellulaire. Cette composition comprend un agent polyvalent qui se lie à un antigène de surface hautement exprimé présent sur la surface d'une cellule. De préférence, l'antigène de surface est associé au cytosquelette de la cellule. Un agent polyvalent préféré est un IgM et l'ajout d'un agent de réticulation permet d'améliorer la fragilisation et la mort cellulaires. A des concentrations sublétales in vivo, les anticorps de fragilisation cellulaire perméabilisent les cellules et améliorent considérablement la réponse aux agents chimiothérapeutiques, y compris chez les patients réfractaires aux agents chimiothérapeutiques.
Bhat Neelima M.
Bieber Marcia M.
Sanders Martin E.
Teng Nelson N. H.
Palingen Inc.
Smart & Biggar
The Board Of Trustees Of The Leland Stanford Junior University
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