C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/10 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) A61P 31/18 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 5/20 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2402054
The present invention demonstrates that a receptor, named DC-SIGN, is specifically expressed on dendritic cells, and facilitates infection of T lymphocytes with HIV Assays for identifying compounds that modulate the interaction of DC-SIGN and HIV and/or T cells and macrophage are provided. Compounds so identified are also part of the present invention.
La présente invention montre qu'un récepteur désigné sous le nom DC-SIGN est exprimé de façon spécifique dans des cellules dendritiques et facilite l'infection des lymphocytes T par le VIH. L'invention concerne des dosages pour identifier les composés qui modulent l'interaction de DC-SIGN et de VIH et/ou lymphocytes T et du macrophage. Les composés ainsi identifiés font également partie de cette invention.
Geijtenbeek Teunis
Kwon Douglas
Littman Dan R.
Van Kooyk Yvette
Katholieke Universiteit Nijmegen
New York University
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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