Antibody inhibitors of gdf-8 and uses thereof

Details Antibody inhibitors of gdf-8 and uses thereof Antibody inhibitors of gdf-8 and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 21/00 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) C07K 14/475 (2006.01)

Patent

CA 2469230

The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.

L'invention concerne des nouveaux anticorps contre la croissance et la différentiation du facteur-8 (GDF-8), notamment des fragments d'anticorps, inhibant l'activité de GDF-8 in vitro etin vivo.. L'invention concerne également des procédés de diagnostic, de prévention et de traitement de troubles dégénératifs des métabolismes musculaire, osseux et de l'insuline.

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