Antibody-mediated disruption of quorum sensing in bacteria

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 17/00 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61P 31/04 (2006.01) C07K 5/00 (2006.01) C07K 7/54 (2006.01) C07K 14/31 (2006.01) C07K 16/00 (2006.01) C07K 16/12 (2006.01) C12N 15/13 (2006.01) C40B 30/04 (2006.01) G01N 33/531 (2006.01)

Patent

CA 2703133

The invention provides an immunogenic molecular entity, a supramolecular assembly, and an antibody that can be used to inhibit Gram-positive bacterial quorum sensing, prevent infection or development of a disease condition associated with a Gram-positive bacterial infection. The invention also provides methods of inhibiting Gram-positive bacterial quorum sensing, and methods of preventing infection or development of a disease condition associated with a Gram-positive bacterial infection.

L'invention porte sur une entité moléculaire immunogène, sur un ensemble supramoléculaire et sur un anticorps pouvant inhiber la détection du quorum chez des bactéries Gram positif et prévenir l'infection ou le développement d'un état morbide associé à une infection par une bactérie Gram positif. L'invention porte également sur des méthodes d'inhibition de la détection du quorum chez des bactéries Gram positif, et sur des méthodes de prévention d'une infection ou du développement d'un état morbide associé à une infection par une bactérie Gram positif.

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