Antibody modulating the differentiation and function of...

C - Chemistry – Metallurgy – 07 – K

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2733529

The present invention relates to an antibody binding to human intercellular adhesion molecule-1 (ICAM-1) where the antibody is able to modulate the differentiation status of dendritic cells and prolong the graft survival. In addition, the present invention provides a pharmaceutical composition comprising the antibody, and method of using them for the treatment of disease.

La présente invention porte sur un anticorps se liant à la molécule d'adhésion intercellulaire humaine-1 (ICAM-1), où l'anticorps est capable de moduler l'état de différenciation de cellules dendritiques et de prolonger la survie de greffe. De plus, la présente invention porte sur une composition pharmaceutique comprenant l'anticorps, et sur un procédé pour les utiliser pour le traitement d'une maladie.

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