C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 19/02 (2006.01) A61P 37/06 (2006.01) C07K 16/24 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01)
Patent
CA 2380298
There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF.alpha.. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF.alpha..
L'invention concerne des molécules d'anticorps contenant au moins un CDR provenant d'un anticorps monoclonal de souris et présentant une spécificité pour TNF.alpha. humain. L'invention concerne également un anticorps greffé CDR dans lequel au moins l'un des CDR est un CDR hybride. L'invention concerne en outre des séquences ADN codant pour les chaînes de molécules d'anticorps, des vecteurs, des cellules hôtes transformées, ainsi que des utilisations des molécules d'anticorps dans le traitement de maladies médiatisées par TNF.alpha..
Athwal Diljeet Singh
Brown Derek Thomas
Chapman Andrew Paul
King David John
Popplewell Andrew George
Celltech R&d Limited
Mcfadden Fincham
Ucb Pharma S.a.
LandOfFree
Antibody molecules having specificity for human tumor... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibody molecules having specificity for human tumor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibody molecules having specificity for human tumor... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1513107