Antibody preparation

Details Antibody preparation Antibody preparation

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2070659

Ligands with a binding affinity for the CD3 antigen having at least one CDR which is of different origin to the variable framework region and/or the constant region of the ligand, the at least one CDR being selected from the amino acid sequences: (a) Ser-Phe-Pro-Met-Ala, (b) Thr-Ile-Ser-Thr-Ser-Gly-Gly-Arg-Thr-Tyr-Tyr-Arg- Asp-Ser-Val-Lys-Gly, (c) Phe-Arg-Gln-Tyr-Ser- Gly-Gly-Phe-Asp-Tyr, (d) Thr-Leu-Ser-Ser-Gly-Asn-Ile-Glu-Asn-Asn-Tyr-Val-His, (e) Asp-Asp-Asp-Lys-Arg-Pro-Asp, (f) His-Ser-Tyr-Val-Ser-Ser-Phe-Asn-Val, and conservatively modified variants thereof, are of therapeutic value, particularly in the control of graft rejection.

Ligants possédant une affinité de liaison avec l'antigène CD3 et comportant au moins une région de détermination de complémentarité (CDR) d'origine différente de la région de structure variable et/ou de la région constante du ligand, ladite région CDR étant sélectionnée à partir des séquences amino-acides suivantes: (a) Ser-Phe-Pro-Met-Ala, (b) Thr-Ile-Ser-Thr-Ser-Gly-Gly-Arg-Thr-Tyr-Tyr-Arg-Asp-Ser-Val-Lys-Gly, (c) Phe-Arg-Gln-Tyr-Ser-Gly-Gly-Phe-Asp-Tyr, (d) Thr-Leu-Ser-Ser-Gly-Asn-Ile-Glu-Asn-Asn-Tyr-Val-His, (e) Asp-Asp-Asp-Lys-Arg-Pro-Asp, (f) His-Ser-Tyr-Val-Ser-Ser-Phe-Asn-Val, ainsi que des variantes ayant subi des modifications sans effets sensibles sur l'affinité anticorps-antigène. Lesdits ligands présentent une valeur thérapeutique, particulièrement dans le contrôle des rejets de greffes.

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