Antibody producing non-human mammals

Details Antibody producing non-human mammals Antibody producing non-human mammals

A - Human Necessities

01

K

A01K 67/027 (2006.01) C07K 16/00 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2729095

The invention provides transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. The invention further provides methods for producing an immunoglobulin from the transgenic, non-human animal.

Linvention concerne des animaux transgéniques non humains qui possèdent un acide nucléique codant une chaîne légère dimmunoglobuline, au moyen desquels la chaîne légère dimmunoglobuline est humaine, de type humain ou humanisée. Lacide nucléique est doté dun moyen qui le rend résistant aux réarrangements de lADN et/ou aux hypermutations somatiques. Dans un mode de réalisation, lacide nucléique comporte une cassette dexpression destinée à lexpression dune molécule souhaitée dans des cellules pendant une certaine étape du développement des cellules se développant en cellules B adultes. Linvention concerne en outre des procédés de production dune immunoglobuline à partir de lanimal transgénique non humain.

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