C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 1/20 (2006.01) C07K 16/00 (2006.01) C07K 16/06 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2214633
A process for purifying an antibody is provided. In this process, a mixture containing the antibody and a contaminant is subjected to low pH hydrophobic interaction chromatography (LPHIC) at low salt concentration. The antibody is eluted from the column in the fraction which does not bind thereto. This process can be preceded and followed by other purification steps.
La présente invention décrit un procédé de purification d'anticorps. Dans ce procédé, un mélange contenant un anticorps et un contaminant est soumis à une chromatographie d'interaction hydrophobe à pH faible (LPHIC) à concentration de sel faible. La partie de l'anticorps qui ne se lie pas au contaminant est éluée de la colonne. Ce procédé peut être précédé et suivi d'autres étapes de purification.
Rinderknecht Ernst H.
Zapata Gerardo A.
Dennison Associates
Genentech Inc.
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