C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07C 63/04 (2006.01) C07C 63/06 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2400622
The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis. Furthermore, it relates to the use of radiolabelled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and suitable photoactive molecules (e.g. an appropriately chosen photosensitizer or radionuclide), and their use for the selective light-mediated occlusion of new blood vessels.
La présente invention concerne des anticorps ayant une affinité sous-nanomolaire spécifique à un épitope caractéristique du domaine ED-B de la fibronectine, un marqueur d'angiogenèse. L'invention concerne également l'utilisation d'anticorps anti ED-B radiomarqués ayant une affinité élevée, pour la détection de vaisseaux sanguins nouvellement formés <i>in vivo</i>, et un ensemble diagnostique contenant ledit anticorps. L'invention concerne par ailleurs des conjugués contenant lesdits anticorps et des molécules photoactives adaptées (par ex. un photosensibilisateur ou un radionucléide choisis de manière appropriée), ainsi que leur utilisation pour l'occlusion sélective induite par la lumière de nouveaux vaisseaux sanguins.
Birchler Manfred
Neri Dario
Tarli Lorenzo
Viti Francesca
Eidgenossische Technische Hochschule Zurich
Marks & Clerk
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