Antibody specific to interleukin 18 precursor

Details Antibody specific to interleukin 18 precursor Antibody specific to interleukin 18 precursor

C - Chemistry, Metallurgy

12

N

C12N 5/12 (2006.01) A61K 39/395 (2006.01) C07K 14/54 (2006.01) C07K 16/24 (2006.01) C12P 21/08 (2006.01) G01N 33/535 (2006.01)

Patent

CA 2324168

Disclosed are an antibody specific to interleukin 18 (IL-18) precursor, preparation processes therefor, and uses thereof. The antibody includes immunoglobulins in both forms of polyclonal and monoclonal antibodies which exhibits an immunoreactivity against IL-18 precursor at an intensity higher than against other substances. The antibody is useful in detection and purification of IL-18 precursor and in elimination and detoxification of the precursor accumulated in vivo. The detection method using the antibody is effective in qualitative and quantitative analyses for the precursor as well as in correction of imprecise results caused by assays using anti-IL-18 antibody which exhibits a cross reactivity against the precursor.

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