C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/02 (2006.01) A61K 49/00 (2006.01) A61K 49/16 (2006.01) A61K 51/10 (2006.01) C07K 16/00 (2006.01) C07K 16/26 (2006.01) C07K 16/28 (2006.01) G01N 33/544 (2006.01)
Patent
CA 2744344
A nanoconjugate is formed from a self-assembled unilamellar vesicle (ULV), at least one contrast agent which may be a MRI contrast agent, a radioisotope or a fluorophore, and at least one antibody, which may be an IgG or an antibody fragment such as a single-domain antibody. The nanoconjugate be targetted with the antibody to receptors specific to certain disease states, and thus be used in diagnostic and imaging methods using the properties o contrast agent.
La présente invention concerne un nanoconjugué qui est formé à partir dune vésicule unilamellaire autoassemblée (ULV), au moins un agent de contraste qui peut être un agent de contraste IRM, un radio-isotope ou un fluorophore, et au moins un anticorps, qui peut être un IgG ou un fragment danticorps tel quun anticorps à domaine unique. Le nanoconjugué peut être ciblé avec lanticorps vers des récepteurs spécifiques de certains états pathologiques, et ainsi être utilisé dans des procédés diagnostiques et dimagerie en utilisant les propriétés de lagent de contraste.
Abulrob Abedelnasser
Iqbal Umar
Katsaras John
Nieh Mu-Ping
Stanimirovic Danica
Bennett Jones Llp
National Research Council Of Canada
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