C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/535 (2006.01) C07K 14/54 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2648484
The present invention relates to fusion proteins comprising an antibody, functional fragment or functional derivative thereof having specific binding affinity to either the extracellular domain of oncofetal fibronectin (ED-B) or at least one of the extracellular domains of oncofetal tenascin fused to a cytokine selected from the group consisting of IL-10, IL15, IL-24 and GM-CSF, functional fragments and functional derivatives thereof. The invention is also directed to the use of at least one of said fusion proteins for the manufacture of a medicament. In particular, the invention concerns the use of said medicament for the treatment of tumours or chronic inflammatory diseases such as atherosclerosis, arthritis and psoriasis.
La présente invention concerne des protéines de fusion comprenant un anticorps, un fragment fonctionnel ou un dérivé fonctionnel de celui-ci ayant une affinité de liaison spécifique au domaine extracellulaire de la fibronectine oncofAEtale (ED-B) ou au moins à l'un des domaines extracellulaires de la ténascine oncofAEtale fusionné à une cytokine choisie dans le groupe comprenant l'IL-10, l'IL-15, l'IL-24 et le GM-CSF, leurs fragments fonctionnels et leurs dérivés fonctionnels. L'invention concerne également l'utilisation d'au moins une desdites protéines de fusion pour la fabrication d'un médicament. En particulier, l'invention concerne l'utilisation dudit médicament pour le traitement de tumeurs de maladies inflammatoires chroniques telles que l'athérosclérose, l'arthrite ou le psoriasis.
Kaspar Manuela
Neri Dario
Trachsel Eveline
Marks & Clerk
Philogen Spa
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