C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61P 31/00 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) G01N 33/53 (2006.01) A61K 51/10 (2006.01)
Patent
CA 2464472
The present invention provides antibody targeting compounds in which the specificity of the antibody has been reprogrammed by covalently or noncovalently linking a targeting agent to the combining site of an antibody. By this approach, the covalently modified antibody takes on the binding specificity of the targeting agent. The compound may have biological activity provided by the targeting agent or by a separate biological agent. Various uses of the invention compounds are provided.
La présente invention a trait à des composés de ciblage d'anticorps, dans lesquels la spécificité de l'anticorps a été reprogrammée par l'établissement d'une liaison covalente ou non covalente entre un agent de ciblage et le site anticorps d'un anticorps. Par cette approche, l'anticorps modifié par covalence prend en charge la spécificité de liaison de l'agent de ciblage. Le composé peut présenter une activité biologique assurée par l'agent de ciblage ou par un autre agent biologique. L'invention concerne également diverses utilisations des composés de l'invention.
Barbas Carlos F.
Lerner Richard
Rader Christoph
Sinha Subhash C.
Fetherstonhaugh & Co.
The Scripps Research Institute
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