Antibody targeting osteoclast-associated protein

Details Antibody targeting osteoclast-associated protein Antibody targeting osteoclast-associated protein

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2555848

A method of detecting bone metabolic disorder by using a gene strongly expressed in osteoclasts; a method of screening a compound having an effect of treating and/or preventing bone metabolic disorder; and a medicinal composition for treating and/or preventing bone metabolic disorder. Namely, a method of detecting bone metabolic disorder by using the expression of human DC-STAMP gene as an indication; a medicinal composition containing an antibody which specifically recognizes human DC-STAMP and has an activity of inhibiting the formation of osteoclasts, etc.

Procédé de détection d'un trouble du métabolisme osseux en utilisant un gène fortement exprimé dans des ostéoclastes ; procédé de recherche par criblage d'un composé ayant un effet de traitement et/ou de prévention d'un trouble du métabolisme osseux ; et composition médicinale pour traiter et/ou prévenir un trouble du métabolisme osseux. A savoir, procédé de détection d'un trouble du métabolisme osseux en utilisant l'expression du gène de la protéine DC-STAMP humaine comme indication ; composition médicinale contenant un anticorps qui reconnaît de façon spécifique la protéine DC-STAMP humaine et a une activité d'inhibition de la formation d'ostéoclastes, etc.

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