Antibody targeting osteoclast-related protein siglec-15

Details Antibody targeting osteoclast-related protein siglec-15 Antibody targeting osteoclast-related protein siglec-15

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 31/122 (2006.01) A61K 31/352 (2006.01) A61K 31/565 (2006.01) A61K 31/593 (2006.01) A61K 31/663 (2006.01) A61K 38/23 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2698326

To provide a method of detecting abnormal bone metabolism by using a gene strongly expressed in an osteoclast; a method of screening a compound having a therapeutic and/or preventive effect on abnormal bone metabolism; and a pharmaceutical composition for treating and/or preventing abnormal bone metabolism. [Means for Resolution] Provision of a method of detecting abnormal bone metabolism by using the expression of human Siglec-15 gene as an index; a pharmaceutical composition containing an antibody which specifically recognizes human Siglec-15 and has an activity of inhibiting osteoclast formation; and the like.

La présente invention concerne un procédé de détection d'une anomalie du métabolisme osseux en utilisant un gène s'exprimant fortement dans les ostéoclastes; l'invention concerne également un procédé de criblage d'un composé ayant un effet de traitement et/ou de prévention d'une anomalie du métabolisme osseux; et une composition médicinale pour traiter et/ou prévenir une anomalie du métabolisme osseux. L'invention concerne en outre un procédé de détection d'une anomalie du métabolisme osseux en utilisant l'expression du gène de la Siglec-15 humaine comme indicateur; L'invention concerne de plus une composition médicinale contenant un anticorps qui possède une activité de reconnaissance spécifique de la Siglec-15 humaine et inhibant la formation d'ostéoclastes; et ainsi de suite.

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