Antibody to cytolethal distending toxin of campylobacter jejuni

Details Antibody to cytolethal distending toxin of campylobacter jejuni Antibody to cytolethal distending toxin of campylobacter jejuni

C - Chemistry, Metallurgy

07

K

C07K 16/12 (2006.01) A61K 39/106 (2006.01) A61K 39/40 (2006.01) A61P 1/00 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) G01N 33/48 (2006.01) G01N 33/564 (2006.01) C07K 14/205 (2006.01)

Patent

CA 2752033

Methods for preventing IBS, reducing the likelihood of developing IBS and/or treating IBS by administering COT inhibitors and/or COT neutralizers to a subject in need thereof are described. Methods of eliciting a specific immune response and methods of vaccinating a subject to prevent IBS or to reduce the likelihood of developing or having IBS are also provided. Methods of diagnosing IBS by detecting the presence or absence of COT or a COT marker in a subject are described.

La présente invention concerne des méthodes permettant de prévenir l'IBS (irritable bowel syndrome), de réduire la probabilité de développer l'IBS et/ou de traiter l'IBS par l'administration d'inhibiteurs de CDT (cytolethal distending toxin) et/ou de neutraliseurs de CDT à un patient en ayant besoin. L'invention concerne également des méthodes permettant d'éliciter une réponse immunitaire spécifique et des méthodes de vaccination d'un patient pour prévenir l'IBS ou pour réduire la probabilité de développer ou d'avoir l'IBS. L'invention concerne également des méthodes permettant de diagnostiquer IBS par la détection de la présence ou de l'absence de CDT ou d'un marqueur de CDT chez un patient.

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