Antibody to human insulin-like growth factor

Details Antibody to human insulin-like growth factor Antibody to human insulin-like growth factor

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 13/12 (2006.01) A61P 35/00 (2006.01) C07K 16/22 (2006.01) C07K 16/26 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2483848

To efficiently treat diseases such as cancer in which hIGF participates, there have been required antibodies which strongly bind to both of hIGF-I and hIGF- II and inhibit their functions and fragments of these antibodies. It is intended to provide antibodies which can specifically bind respectively to human IGF-I and human IGF-II to thereby inhibit the functions of human IGF-I and human IGF-II and have binding activity with a binding constant of 5×109 M-1 or more measured with a biosensor BIACORE. It is also intended to provide diagnostics, preventives and remedies comprising the above antibodies for an hIGF-mediated disease and a disease showing pathological progressing due to abnormally accelerated hIGF production.

En vue de traiter efficacement des maladies telles que le cancer, avec intervention de hIGF, on a recours à des anticorps qui se lient solidement, à la fois, à hIGF-I et à hIGF-II et inhibent leurs fonctions, et à des fragments de ces anticorps. L'invention concerne des anticorps pouvant se lier spécifiquement à IGF-I humain et à IGF-II humain, de manière à inhiber les fonctions de IGF-I humain et IGF-II humain, et qui présentent une activité de liaison ayant une constante de liaison de 5 x 10?9¿ M?-1¿, ou plus, mesurée au moyen d'un biodétecteur BIACORE. L'invention concerne également des agents de diagnostic, des moyens préventifs et des remèdes comprenant les anticorps précités pour des maladies où intervient hIGF, et des maladies présentant une progression pathologique due à une production de hIGF anormalement accélérée.

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