Antibody to smooth muscle myosin heavy chains

Details Antibody to smooth muscle myosin heavy chains Antibody to smooth muscle myosin heavy chains

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) C07K 14/47 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2050941

Using as an immunogen an oligopeptide containing a different portion of the amino acid sequence of isoform SM-l, SM-2 or SM-3 in smooth muscle myosin heavy chains, for example, the C-terminus amino acid sequence, antibodies capable of distinctly recognizing each isoform from other of the smooth muscle myosin heavy chains can be obtained. The antibodies are useful as reagents for tissue staining and also useful as diagnostic reagents of vascular disturbance or arteriosclerosis.

séparément l'une de l'autre. On produit cet anticorps en utilisant comme immunogène un oligopeptide contenant la partie d'isoforme SM-1, SM-2 ou SM-3 dans laquelle la séquence d'acides aminés est différente, par exemple une séquence d'acides aminés de la terminaison C. On utilise cet anticorps en tant que réactif pour la coloration histologique des muscles lisses, ou pour le diagnostic des troubles des vaisseaux sanguins, de l'artériosclérose, etc.

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