Antibody tools for the diagnostic use in the medical therapy...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/18 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C12N 5/16 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2500384

The invention relates to a method for determining whether a treatment of a disorder with an HDAC inhibitor is to be started/continued or not comprising determining the level of histone acetylation in the sample by use of an antibody capable of binding to acetylated histone, and classifying the disorder as to be treated with an HDAC inhibitor when the level of histone acetylation is significantly lower than that of a reference sample. The invention further relates to the diagnostic and prognostic use of specific antibodies and cell lines producing them.

L'invention concerne un procédé destiné à déterminer si un traitement d'un trouble avec un inhibiteur HDAC doit être commencé/continué ou à exclure la détermination du niveau d'acétylation d'histone dans l'échantillon par utilisation d'un anticorps capable de se lier à l'histone acétylé, et à classifier le trouble à traiter avec un inhibiteur HDAC lorsque le niveau d'acétylation d'histone est sensiblement inférieur à celui d'un échantillon de référence. L'invention concerne enfin l'utilisation d'anticorps spécifiques dans le diagnostic et le pronostic ainsi que des lignées cellulaires produisant ces anticorps.

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