C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) G01N 33/53 (2006.01) G06F 17/00 (2006.01)
Patent
CA 2627075
Methods and compositions directed to improved universal antibody libraries that rationally exploit human diversity information contained within reference antibody libraries, such as universal antibody libraries, are disclosed. The disclosed processes involve use of a query CDR sequence to guide incorporation of human antibody diversity present within the reference library into cohort libraries of the invention. Methods for making and screening such cohort libraries for isolating therapeutics suitable for treating disease are also disclosed.
Procédés et compositions se rapportant à des librairies d'anticorps universelles qui exploitent rationnellement l'information de diversité humaine propre à des librairies d'anticorps de référence, du type librairies d'anticorps universelles. Les procédés décrits reposent sur l'utilisation d'une séquence CDR d'interrogation pour guider l'incorporation de la diversité humaine d'anticorps en question propre à une librairie de référence dans les librairies de type cohorte décrites. L'invention concerne également des procédés d'élaboration et d'analyse de ces librairies de type cohorte pour l'isolation de moyens thérapeutiques appropriés au traitement de maladies.
Bayez Nurten
Bhatt Ramesh
Cappucilli Guido
Crea Roberto
Shen Randy
Bioren Inc.
Torys Llp
LandOfFree
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