Antibody variants having modifications in the constant region

Details Antibody variants having modifications in the constant region Antibody variants having modifications in the constant region

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2745439

The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of lgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.

La présente invention concerne des positions dans la région constante d'anticorps, en particulier la région CH3 de lgG4, qui affectent la force des interactions CH3-CH3. L'invention concerne des mutations qui stabilisent ou déstabilisent cette interaction.

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