Antibody variants with faster antigen association rates

Details Antibody variants with faster antigen association rates Antibody variants with faster antigen association rates

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/22 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01) C12N 15/09 (2006.01) C12P 21/02 (2006.01) G01N 33/557 (2006.01)

Patent

CA 2472922

Antibody variants with faster antigen association rates are disclosed. The antibody variants have one or more amino acid alteration(s) in or adjacent to at least one hypervariable region thereof which increase charge complementarity between the antibody variant and an antigen to which it binds.

L'invention concerne des variantes d'anticorps ~ vitesses d'association d'antig­ne acc~l~r~es. Lesdites variantes d'anticorps pr~sentent une ou plusieurs alt~ration(s) d'acides amin~s ou sont adjacentes ~ au moins une r~gion hypervariable desdits acides, ce qui augmente la compl~mentarit~ de charge entre la variante d'anticorps et l'antig­ne auquel il est li~.

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