Antibody variants with higher binding affinity compared to...

Details Antibody variants with higher binding affinity compared to... Antibody variants with higher binding affinity compared to...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/22 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2347833

Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.

L'invention concerne des variants d'anticorps par rapport à des anticorps d'origine, caractérisés en ce qu'un ou plusieurs acides aminés sont insérés dans une région hypervariable de l'anticorps d'origine, et présentant une affinité de liaison vis-à-vis d'un antigène cible au moins deux fois plus forte que l'affinité de liaison de l'anticorps d'origine pour l'antigène considéré.

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