Anticalcification treatment for aldehyde-tanned biological...

Details Anticalcification treatment for aldehyde-tanned biological... Anticalcification treatment for aldehyde-tanned biological...

A - Human Necessities

01

N

A01N 1/02 (2006.01) A61F 2/24 (2006.01) A61L 27/36 (2006.01) C14C 3/16 (2006.01) C14C 9/04 (2006.01)

Patent

CA 2117557

A method of treating aldehyde-tanned biological tissue minimizes in vivo calcification and reduces cytotoxicity without impairing the mechanical strength of the tanned tissue. The method includes the step of treating the aldehyde-tanned biological tissue with at least one liquid polyol having formula (I), where R is CH2OH or an alkyl group, and R' is H, an alkyl group or an O-acyl where the acyl is C2-C9 or a carboxyalkyl; or formula (II) where R is H or an alkyl group, and R' is H, an alkyl group, O-alkyl or O-carboxyalkyl. Preferred polyols are propylene glycol, 1,3-propanediol, 2,3-butylene glycol and glycerol, and the polyol is preferably a diol.

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