Anticalcification treatments for fixed biomaterials

Details Anticalcification treatments for fixed biomaterials Anticalcification treatments for fixed biomaterials

A - Human Necessities

61

L

A61L 27/50 (2006.01) A61L 27/36 (2006.01)

Patent

CA 2393438

A method for treating biomaterial is provided in which a biological tissue, typically after being cross-linked, is contacted with an anticalcification treatment solution under condition effective to render the biomaterial resistant to in vivo calcification upon implantation in a host animal. The anticalcification treatment solutions comprise higher alcohol solutions, a polyol solutions and/or a polar aprotic organic solvent solutions.

L'invention concerne un procédé de traitement d'une biomatière dans lequel un tissu biologique, généralement après réticulation, est mis en contact avec une solution de traitement anti-calcification dans des conditions efficaces pour rendre ladite biomatière résistante à une calcification in vivo à la suite de son implantation dans un animal hôte. Les solutions de traitement anti-calcification comprennent des solutions à base d'alcools supérieurs, des solutions d'un polyol et/ou des solutions d'un solvant organique aprotique polaire.

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