Anticancer agent

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/20 (2006.01) A61K 31/122 (2006.01) A61K 31/19 (2006.01) A61K 31/201 (2006.01) A61K 31/23 (2006.01) A61K 31/231 (2006.01) A61K 31/357 (2006.01) A61K 31/365 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2396638

Drugs, in particular, anticancer agents. More particularly speaking, anticancer agents which contain as the active ingredient(s) one or more compounds selected from among .omega.-hydroxyfatty acids having a specific chemical structural formula and salts and esters thereof, hydroxyoxofatty acids and salts and esters thereof, lactone compounds, macrocyclic ketones and macrocyclic diesters. The above-described compounds have a carcinostatic effect, an extremely high effect of preventing cancer metastasis, an effect of preventing recurrence of cancer, an effect of preventing the occurrence of cancer and little cytotoxicity. Moreover, these compounds are efficacious only in a small dose. Owing to these characteristics, these compounds enable the provision of anticancer agents with little side effect. The effect of preventing cancer metastasis can be further enhanced by the combined use with known anti-malignant tumor agents. Among the anticancer agents as described above, .omega.-hydroxyfatty acids can be very conveniently obtained at a high purity by hydrolyzing lactone compounds which are also the anticancer agents as described herein.

La présente invention concerne des médicaments notamment des agents anticancéreux et plus particulièrement des agents anticancéreux qui renferment en tant qu'ingrédient(s) actif(s) un ou plusieurs composés sélectionnés parmi des acides gras .omega.-hydroxy ayant une formule chimique développée spécifique, ainsi que parmi leurs sels et leurs esters, des composés lactone, des cétones macrocycliques et des diesters macrocycliques. Les composés présentés ci-avant ont un effet carcinogène, un effet extrêmement important d'inhibition des métastases cancéreuses, un effet d'inhibition de la récurrence du cancer et une faible toxicité. En outre, ces composés sont efficaces uniquement à faible dose. Du fait de ces caractéristiques, ces composés permettent d'utiliser des agents anticancéreux avec peu d'effets secondaires. L'effet d'inhibition des métastases cancéreuses peut en outre être renforcé par l'utilisation combinée avec des agents anti-tumeurs malignes. Parmi les agents anticancéreux susmentionnés, on peut produire très commodément des acides gras .omega.-hydroxy, de grande pureté, par hydrolyse de composés lactone qui sont également les agents anticancéreux décrits ci-avant.

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