A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61K 31/337 (2006.01) A61K 31/475 (2006.01) A61K 31/555 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2599150
The invention relates to the medicinal field. An anticancer agent composition is provided which comprises a combination of (a) at least one of paclitaxel, carboplatin, irinotecan, and derivatives of these and (b) a protein which is a diphtheria toxin mutant, has the ability to inhibit the bonding of HB-EGF to an EGF receptor, and has substantially no toxicity of diphtheria toxin. Also provided is a kit for cancer remedy which comprises the ingredients (a) and (b). Use of (a) and (b) in combination synergistically produces an excellent growth inhibitory effect on tumors.
L~invention concerne le domaine médical. Une composition d~agent anticancéreux est fournie qui comprend une combinaison de (a) au moins un de paclitaxel, carboplatine, irinotécan, et des dérivés de ceux-ci et (b) une protéine qui est un mutant de toxine de diphtérie. Cette composition est capable de bloquer la liaison HB-EGF à un récepteur EGF, et ne présente sensiblement aucune toxicité de la toxine de diphtérie. L~invention a également trait à un kit de remède contre le cancer qui comprend les ingrédients (a) et (b). L'utilisation de (a) et (b) en association produit de manière synergique un excellent effet d'inhibition de la croissance des tumeurs.
Mekada Eisuke
Miyamoto Shingo
Kirby Eades Gale Baker
The Research Foundation For Microbial Diseases Of Osaka Universi
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