Anticancer agents

Details Anticancer agents Anticancer agents

A - Human Necessities

61

K

A61K 31/496 (2006.01) A61P 35/00 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2385996

Use as anticancer agents of diphenylmethylpiperazines represented by general formula [1]: <see formula I> wherein R represents (.alpha.) or (.beta.). Compared with the conventional anticancer agents, these anticancer agents are less toxic and exert an excellent carcinostatic effect on various solid cancers. Moreover, these anticancer agents inhibit the proliferation of fibroblasts, which makes them efficacious against pulmonary fibrosis and proliferative keloid lesion.

Cette invention se rapporte à des dérivés de diphénylméthylpipérazine qui constituent des agents anticancéreux se caractérisant en ce qu'ils sont constitués par des composés représentés par la formule générale (I), des sels, des dérivés ou des promédicaments de ces composés. Dans cette formule, R représente ( alpha ) ou ( beta ). Comparés aux agents anticancéreux traditionnels, ces agents anticancéreux sont moins toxiques et ils exercent un excellent effet carcinostatique sur divers cancers solides. Ces agents anticancéreux empêchent en outre la prolifération des fibroblastes, ce qui les rend efficaces contre la fibrose pulmonaire et la lésion chéloïde proliférative.

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