Anticancer agents and preparation method of the same

Details Anticancer agents and preparation method of the same Anticancer agents and preparation method of the same

C - Chemistry, Metallurgy

08

G

C08G 65/337 (2006.01) A61K 31/409 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07D 487/22 (2006.01)

Patent

CA 2458744

Antitumor agents containing, as the active ingredient, a metal porphyrin derivative having a hemoxygenase activity and bonded to an amphipathic or water-soluble polymer (in particular, Zn-protoporphyrin (Zn-PP) bonded to polyethylene glycol). Because of being bonded to an amphipathic or water- soluble polymer such as polyethylene glycol, the active ingredient can be administered by intravenous injection and can exert a remarkable antitumor effect owing to tumor-selective delivery.

L'invention concerne des agents anticancéreux contenant, en tant qu'ingrédient actif, un dérivé de porphyrine métallique ayant une activité d'hème oxygénase et lié à un polymère amphipathique ou hydrosoluble (plus spécifiquement Zn-protoporphyrine (Zn-PP) liée à polyéthylène glycol). Etant donné qu'il est lié à un polymère amphipathique ou hydrosoluble tel qu'un polyéthylène glycol, l'ingrédient actif peut être administré par injection intraveineuse et peut exercer un effet anticancéreux remarquable grâce à un apport centré sur la tumeur.

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