C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/18 (2006.01) A61K 31/357 (2006.01) A61P 33/02 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01)
Patent
CA 2570961
This invention comprises compositions containing dihydroartemisinin- and dihydroartemisitene- dimers with activity as anticancer or anticancer metastasis agents and anti-protozal, including anti-malarial and anti- leishmanial properties. This invention also describes methods of preparation of these compositions and methods of use of such compositions for the treatment of cancer or prevention of cancer metastasis, and protozoal infections, including malaria, or leishmaniasis. The compounds of this invention represent a potential new class of anti-tumor or anti-metastasis agents, one that has shown promising activity against solid tumors.
L'invention concerne des compositions qui renferment des dimères dihydroartémisinine et dihydroartémisitène anticancéreux ou antimétastase cancéreuse et antiprotozoaires, ayant aussi des propriétés antipaludiques et antileishmaniose. On décrit par ailleurs des procédés d'élaboration pour ces compositions et des procédés d'utilisation correspondants pour le traitement du cancer ou la prévention de la métastase cancéreuse, des infections protozoaires, y compris la malaria ou la leishmaniose. Les composés considérés représentent une classe potentielle d'agents antitumoraux ou antimétastase, produisant des effets prometteurs contre les tumeurs solides.
Elsohly Mahmoud A.
Gul Waseem
Sim & Mcburney
University Of Mississippi
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