Anticancer combination therapy including triciribine

A - Human Necessities – 61 – K

Patent

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Details

A61K 45/06 (2006.01) A61K 31/282 (2006.01) A61K 31/337 (2006.01) A61K 31/4353 (2006.01) A61K 31/7076 (2006.01) A61K 33/24 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2724246

This invention encompasses combination therapies including TCN, TCN-P, TCN-PM and/or related compounds and one or more additional anti-cancer agents, for example, taxanes a molecule that modulates the HER2/neu (erbB2) receptor, anthracyclin compounds, epidermal growth factor receptor inhibitor compounds, one or more platinum compounds and bortezomib and derivatives thereof and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.

Cette invention concerne des thérapies de combinaison comprenant des composés TCN, TCN-P, TCN-PM et/ou les composés associés et un ou plusieurs agents anticancéreux supplémentaires, par exemple des taxanes, une molécule qui module le récepteur de HER2/neu (erbB2), des composés anthracyclines, des composés inhibiteurs des récepteurs de facteur de croissance épidermique, un ou plusieurs composés de platine et du bortezomib et des dérivés de celui-ci, et des compositions avec une toxicité réduite pour le traitement et la prévention de tumeurs, du cancer et autres troubles associés à une prolifération cellulaire anormale.

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