Anticancer compound and enantiomer separation method useful...

Details Anticancer compound and enantiomer separation method useful... Anticancer compound and enantiomer separation method useful...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4709 (2006.01)

Patent

CA 2398353

The present invention relates to the compound (+)-6-[amino-(6-chloro-pyridin- 3yl)-(3-methyl-3H-imidazol-4-yl)-- methyl]-4-(3-chloro-phenyl)-1-cyclopropylmethyl-1H-quinolin-2-one, pharmaceutically acceptable salts and solvates thereof, pro-drugs thereof, and to the use of said compound for inhibiting abnormal cell growth, including cancer, in mammals. The invention also relates to methods useful in synthesizing the aforementioned compound.

La présente invention concerne le composé (+)-6-[amino-(6-chloro-pyridin-3yl)-(3-méthyl-3H-imidazol-4-yl)-méthyl]-4-(3-chloro-phényl)-1-cyclopropylméthyl-1H-quinolin2-one, ses sels et ses solvates pharmaceutiquement acceptables, les promédicaments de ce dernier et l'utilisation de ce composé pour inhiber la croissance cellulaire anormale, y compris le cancer, chez des mammifères. Cette invention concerne également des procédés utiles dans la synthèse dudit composé.

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