C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/26 (2006.01) A61K 31/4745 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2762233
The invention relates to a compound of formula (I), more specifically in the levorotatory form (1a) thereof, in particular the form having a rotatory power [a]D= -38.6+0.7 at a concentration of 0.698 mg/ml in methanol. The compound may be in the form of a base or an acid addition salt, in particular a pharmaceutically acceptable acid. The compound is a selective Aurora A and B kinase inhibitor and can be used as an anticancer drug.
L'invention est relative au composé de formule (I) plus particulièrement sous sa forme lévogyre (la), notamment celle présentant le pouvoir rotatoire [a]D= -38,6+0,7 à une concentration de 0,698 mg/ml dans le méthanol. Le composé peut exister sous forme de base ou d'un sel d'addition à un acide, notamment un acide pharmaceutiquement acceptable. Ce composé est un inhibiteur sélectif des kinases Aurora A et B. Il peut être utilisé en tant qu'anticancéreux.
Carry Jean-Christophe
Cheve Michel
Clerc Francois
Combeau Cecile
Gontier Sylvie
Robic
Sanofi
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