Anticancer drug enhancer

Details Anticancer drug enhancer Anticancer drug enhancer

A - Human Necessities

61

K

A61K 45/00 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2362426

Combined use of a proteasome activity inhibitor with an anticancer agent containing a topoisomerase activity inhibitor makes it possible to inhibit the proteasome activity of promoting the degradation of topoisomerase. Thus, the presence of a sufficient amount of topoisomerase can be ensured in cancer cells and the effect of the anticancer agent containing the topoisomerase activity inhibitor targeted on topoisomerase can be potentiated. Similarly, combined use of a proteasome activity inhibitor with DNA strand-injury type anticancer agents (for example, platinum complexes, alkylating agents, bleomycins), which directly act on DNA but suffer from regulation or reduction in the effects thereof by the proteasome activity, can potentiate the effects.

L'invention concerne l'utilisation combinée d'un inhibiteur d'activité de protéasome et d'un agent anticancéreux contenant un inhibiteur d'activité de topo-isomérase, qui permet d'inhiber l'activité de protéasome facilitant la dénaturation de topo-isomérase. On assure de cette manière la présence d'une quantité suffisante de topo-isomérase dans des cellules cancéreuses, et on potentialise l'effet de l'agent anticancéreux contenant l'inhibiteur d'activité de topo-isomérase sur la topo-isomérase. De façon similaire, l'utilisation combinée d'un inhibiteur d'activité de protéasome et d'agents anticancéreux du type à lésion de brin d'ADN (par exemple complexes de platine, agents alkylants, bléomycines), qui agissent directement sur l'ADN mais dont les effets sont régulés ou réduits par l'activité de protéasome, permet de potentialiser ces effets.

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