Anticarcinoma antibodies and uses thereof

Details Anticarcinoma antibodies and uses thereof Anticarcinoma antibodies and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 47/48 (2006.01) C07K 16/30 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2547034

There is disclosed herein an amino acid sequence comprising DVQLQASGGG X1,VQPGGSLRL SCAAHDPIFD KNLMGWX2RQA PGKX3X4EX5VAT ISGSGGTNYA SSVEGRFTIS RDNAKKTVYL QMNDLKPEDT AVYYCNSAFA IX6GQGTQVTV SS Wherein Xl is: V, S, D, L, F, W, or T; X2 is: G, F, Y, V, I, H, or L; X3 is: Q, G, E, D, L, R, or K; X4 is: R, C, Q, L, I, P, or K; X5 is: Y, T, A, W, F, S, or L; X6 is: W, R, E, A, G, V, or K. This sequence is useful in the production of antibodies and other proteins capable of recognizing cancer-specific antigens.

L'invention porte sur la séquence d'acides aminés: X¿1?,VQPGGSLRL SCAAHDPIFD KNLMGWX¿2?RQA PGKX¿3?X¿4?EX¿5?VAT ISGSGGTNYA SSVEGRFTIS RDNAKKTVYL QMNDLKPEDT AVYYCNSAFA IX¿6?GQGTQVTV SS, dans laquelle: X¿l? est: V, S, D, L, F, W, ou T; X¿2? est: G, F, Y, V, I, H, ou L; X¿3? ¿is: ?Q, G, E, D, L, R, ou K; X¿4? est: R, C, Q, L, I, P, ou K; X¿5? est: Y, T, A, W, F, S, ou L; et X¿6? est: W, R, E, A, G, V, ou K. Cette séquence est utile pour la production d'anticorps et d'autres protéines, capables de reconnaître les antigènes spécifiques du cancer.

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