Anticoagulant agents

Details Anticoagulant agents Anticoagulant agents

C - Chemistry, Metallurgy

07

K

C07K 5/062 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 38/05 (2006.01) C07C 257/18 (2006.01) C07C 311/06 (2006.01) C07C 311/13 (2006.01) C07D 205/04 (2006.01) C07D 207/16 (2006.01) C07D 209/42 (2006.01) C07D 261/20 (2006.01) C07D 401/06 (2006.01) C07D 413/12 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2258915

This invention relates to a compound of formula (I) X-C(O)-Y-G-R (wherein X, Y, G and R have the values defined in the description), or a pharmaceutically acceptable salt thereof, processes and intermediates for the preparation of such a compound or salt, pharmaceutical compositions comprising such a compound or salt and methods of their use as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders.

La présente invention concerne un composé représenté par la formule générale (I) X-C-(O)-Y-G-R ou l'un de ses sels admis en pharmacie. Dans cette formule générale (I), X, Y, G et R ont la valeur qu'on en donne dans le corps de la demande. L'invention concerne également des procédés et des intermédiaires de préparation d'un tel composé ou sel. L'invention concerne enfin, non seulement des compositions pharmaceutiques comprenant un tel composé ou sel, mais aussi des procédés d'utilisation de ces compositions pharmaceutiques comme inhibiteurs de la thrombine, comme inhibiteurs de coagulation et comme agents de traitement des troubles thromboemboliques.

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