Anticoagulant peptide alcohols

Details Anticoagulant peptide alcohols Anticoagulant peptide alcohols

C - Chemistry, Metallurgy

07

K

167/103, 530/7.0

C07K 7/08 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) C07K 7/06 (2006.01) C07K 14/815 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341354

This invention relates to peptide derivatives of the formula X-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-ol wherein X is hydrogen, or Suc; A1 is a bond, Asp, or Gly-Asp; A2 is Phe or Tyr; A3 is Glu; A4 is Glu or Pro; A5 is Ile; A6 is Pro; A7 is Glu; A8 is Glu, Asp, or Tyr; A9 is Tyr-Leu, Ala-Tyr, Ala-Phe, Ala-Cha, Tyr-Cha, or Leu; A10-of is Gln-ol, Asp-Glu-ol, Pro-ol, D-Lys-ol, Lys-ol, Glu-ol, Asp-ol, Ala-ol, or-ol. which are useful anticoagulant agents.

599040

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