C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 47/48 (2006.01) A61P 7/02 (2006.01) C07K 14/81 (2006.01) A61B 5/00 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2613691
The present invention provides an anticoagulant agent including a first element capable of inhibiting coagulation and a second element capable of targeting an activated platelet wherein upon administration of the agent to a subject the second element directs the first element to the activated platelet. Also provided is a probe for detecting a blood vessel abnormality including (a) a binding element capable of targeting an activated platelet and (b) a label. Applicant has shown that agents and probes directed to activated platelets are useful in the diagnosis and therapy of coagulation disorders.
La présente invention concerne un agent anticoagulant comprenant un premier élément capable d'inhiber la coagulation et un second élément capable de cibler une plaquette activée ; lorsque l'agent est administré à un sujet, le second élément dirige le premier élément vers la plaquette activée. L'invention concerne aussi une sonde permettant de détecter une anomalie vasculaire et comprenant (a) un élément de liaison capable de cibler une plaquette activée et (b) un traceur. Le déposant a démontré que les agents et les sondes dirigés vers les plaquettes activées sont utiles dans le diagnostic et le traitement de troubles de la coagulation.
Baker Medical Research Institute
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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