Anticonvulsant derivatives useful for the treatment of...

A - Human Necessities – 61 – K

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A61K 31/255 (2006.01) A61K 31/35 (2006.01) A61K 31/357 (2006.01) A61K 31/7024 (2006.01) A61K 31/7048 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2417304

Anticonvulsant derivatives of formula (I) for the treating depression as monotherapy or combination therapy are disclosed. Wherein X is CH2 or oxygen; R1 is hydrogen or alkyl; and R2, R3, R4 and R5 are independently hydrogen or lower alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (II): wherein R6 and R7 are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring.

La présente invention concerne des dérivés anticonvulsivants représentés par la formule (I), utilisés en monothérapie ou en polythérapie pour traiter la dépression. Dans cette formule, X représente CH¿2? ou oxygène; R?1¿ représente hydrogène ou alkyle; et R?2¿, R?3¿, R?4¿ et R?5¿ représentent individuellement hydrogène ou alkyle inférieur, et, lorsque X représente CH¿2?, R?4¿ et R?5¿ peuvent représenter des groupes alcènes liés de façon à former un noyau benzène, et, lorsque X représente oxygène, R?2¿ et R?3¿ et/ou R?4¿ et R?5¿ peuvent représenter un groupe methylènedioxy représentés par la formule (II), dans laquelle R?6¿ et R?7¿ sont identiques ou différents et représentent hydrogène ou alkyle inférieur, ou alors alkyle, et sont liés de façon à former un noyau cyclopentyle ou cyclohexyle.

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