Anticonvulsant derivatives useful in treating chronic...

A - Human Necessities – 61 – K

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A61K 31/7048 (2006.01) A61K 31/255 (2006.01) A61K 31/35 (2006.01) A61K 31/357 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2369095

Use of anticonvulsant derivatives of formula (I) for treating chronic neurodegenerative conditions, wherein X is CH2 or oxygen; R1 is hydrogen or C1-C4 alkyl; and R2, R3, R4 and R5 are independently hydrogen or alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of formula (II), wherein R6 and R7 are the same or different and are hydrogen, or alkyl and are joined to form a cyclopentyl or cyclohexyl ring.

L'invention concerne des dérivés anticonvulsivants représentés par la formule (I), utiles pour traiter des troubles neurodégénératifs chroniques, formule (I) dans laquelle X représente CH2 ou oxygène, R1 représente hydrogène ou C1-C4 alkyle, et R2, R3, R4 et R5 sont indépendamment hydrogène ou alkyle et, lorsque X représente CH2, R4 et R5 peuvent représenter des groupes alcènes liés de façon à former un noyau benzène. Lorsque X représente oxygène, R2 et R3 et/ou R4 et R5 associés peuvent représenter un groupe méthylènedioxy de formule (II) dans laquelle R6 et R7 sont identiques ou différents et représentent hydrogène ou alkyle, et sont liés de façon à former un noyau cyclopentyle ou cyclohexyle.

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